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讲座通知:BiO-MEMS in UC Davis and UC Berkeley, 3月25日上午10点,北大微电子所三楼会议室
作者 佚名 摘自 未知 发表 2009-03-17 06:10:57 人气 3574 背景色 杏仁黄 秋叶褐 胭脂红 芥末绿 天蓝 雪青 灰 银河白(默认色) 字号   


Lecture on Bio-MEMS

Novel Approaches for Human Diagnostic Sensors

Dr. Davis, Cristina Elizabeth
of California, Davis

Cell-Matrix Mechanobiology:

Biophysics, Therapeutics, and Biointerfacial Design

Dr. Sanjay Kumar

University of California, Berkeley



Novel Approaches for Human Diagnostic Sensors

Dr. Davis, Cristina Elizabeth

Assistant Professor

University of California, Davis

Volatile organic compounds (VOCs) are generated by almost all biological systems, and are now thought to represent end products associated with organism physiology and metabolism. This applies to many different types of systems ranging from human, bacteria, trees and plants. In humans, several thousand chemical compounds have been detected in exhaled breath and appear to relate to health and disease status. Because of this, breath analysis provides a wide range of opportunities for diagnosis of pathophysiological conditions in a non-invasive and potentially inexpensive way. We hypothesize that specific odor compounds are associated with specific diseases. By monitoring for emitted chemicals, we can develop tools for early stage asymptomatic diagnostics that can lead to early therapy and treatment.

Davis research group is developing multiple approaches to create miniature analytical sensor modules capable of integration into portable devices for human diagnostic systems. Final system integration of devices is expected to yield analyzers that are specifically tailored for each application, have small footprints, and be adapted for field and clinic use. Major areas of interest include: (1) identification of robust chemical biomarkers associated with diseases of interest; (2) miniaturization to produce small, portable and easy-to-use chemical analysis systems; and (3) advanced chemometric algorithms and digital signal processing methods.

“Cell-Matrix Mechanobiology:

Biophysics, Therapeutics, and Biointerfacial Design”

Sanjay Kumar, M.D., Ph.D.

Assistant Professor of Bioengineering

University of California, Berkeley

The ability of a living cell to control its three-dimensional structure is critical to normal tissue physiology. An individual cell derives this morphological control from its cytoskeleton, the three-dimensional network of biopolymers whose collective dynamics and mechanics define cell shape and enable cells to sense, process, and respond to a variety of physical cues in the environment, including mechanical force and the geometry and stiffness of the extracellular matrix (ECM). I will describe several experimental approaches my colleagues and I have taken to understanding how cytoskeletal polymers contribute to cellular mechanics and biophysical crosstalk with the ECM, which include the use of various micro/nanoscale technologies to probe the biophysical properties of contractile and adhesive structures within living cells. I will also discuss our recent efforts to determine the role of cell-ECM mechanobiology in influencing the growth and invasion of tumors of the nervous system, as well as our attempts to leverage cell-ECM mechanobiology to engineer cell fate and assembly in bottom-up tissue engineering systems.

上一篇文章 CFP: 35th MNE2009,Sep28-Oct .
下一篇文章 CFP: OIT'09, Shanghai,19-22 .

ieee-nanomed--Call for paper(CINS,2007-05-07,11757)


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